Shikanoko Nokonoko Koshitantan

-both crazy unrealistical parody anime with realistical animals' images -main girl is too goofy and violent -secondary main character takes care of them  

> Both similar humour, set in a high-school setting. >The serious main character is hiding a secret (assassin/delinquent) >Both main characters are high school girls, one carefree and one serious. > Both ED / OP soundtracks are really catchy!  

Both are slice of life comedy anime focused on absurd situations. "Random weird comedy stuff and deer" would be a great way to desribe them both, as Nokotan is all about deer and Nichijou for some reason has a lot of out of nowhere deer sketches. 

Two gag comedy parodies with unhinged high school girls set mainly in school. The comedy in both are very excessive and meme-y so they're very similar in those regards. 

The mc is someone whos "normal" and is the only one who doesnt think that things in the show are normal. These shows also give u a crazy chaotic fun without any rules and both of them have some real life "troll" footage.  

Both anime have similar type of Gag Comedy and Humor involving an all-girl cast, And Both Anime are by the Same Director.  

"My Deer Friend Nokotan" and "Squid Girl" are both absurd gag comedies involving a human/animal girl coming into society and causing havoc. Some other similarities include: -a very meme opening which is catchy but also gets annoying -similar characters, whose primary characterization revolves around a gag -pretty similar styles of humor, which usually revolves around the main character misunderstanding or being misunderstood by those around them The main difference is that "Squid Girl" takes place on the beach while "My Deer Friend Nokotan" is more of a school anime with school-related jokes. If you like one you'll probably like the other though.  

Similar humor style, meme references, and characterization 

When you have a chaotic duo with absurd comedy and dirty jokes you might like the other anime. 

Similar kinda story structure, where most of it are absurd comedy sketches, but then it actually serves unironically to flesh out the characters and form a path moving forward. Plus, it's all kickstarted by the arrival of a surreal character that needs to be taken care of by the delinquent protagonist of the story. 

Both have hilarious absurd humor with unexpected twists during jokes  

Though Nokotan and Azumanga came from the different era (Reiwa and Heisei respectively), but both of them are high school girls comedy series with many absurd and surreal jokes 

Surreal CGDCT gag comedy with occasional yuri jokes. It helps that the author of the latter is also an experienced yuri mangaka. 

Aho-Girl features a vacuous, vivacious girl whose clingy and often off the wall antics are constantly annoying her co-protagonist. Nokotan is a very similar character, with very similar antics to Yoshiko from Aho-girl, and Koshi plays a similar annoyed "straight man" roll as Akutsu from Aho-Girl.